Publications
2022
Yu Y, Lin H, Liu Q, Ma Y, Zhao L, Li W, Zhou Y, Byun HM, Li P, Li C, Sun C, Chen X, Liu Z, Dong W, Chen L, Deng F, Wu S, Hou S, Guo L.
Sci Total Environ. 2023 Dec 23;912:169549. doi: 10.1016/j.scitotenv.2023.169549.
PMID: 38145684
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Association between diesel exhaust exposure and mitochondrial DNA methylation.
Seow WJ, Hu W, Dai Y, Vermeulen R, Byun HM, Wong JYY, Bassig BA, Blechter B, Duan H, Niu Y, Downward G, Leng S, Ji BT, Fu W, Xu J, Meliefste K, Yang J, Ren D, Ye M, Meng T, Bin P, Hosgood HD, Silverman DT, Rothman N, Zheng Y, Lan Q.
Carcinogenesis. 2022 Dec 31;43(12):1131-1136. doi: 10.1093/carcin/bgac077.
PMID: 36200867
Genomic targets and selective inhibition of DNA methyltransferase isoforms.
Sae-Lee C, Barrow TM, Colicino E, Choi SH, Rabanal-Ruiz Y, Green D, Korolchuk VI, Mathers JC, Byun HM.
Clin Epigenetics. 2022 Aug 20;14(1):103. doi: 10.1186/s13148-022-01325-4.
PMID: 35987848
Guo L, Liu Z, Li P, Ji Y, Song S, Zheng N, Zhao L, Jia Y, Fang J, Wang H, Byun HM.
Ecotoxicol Environ Saf. 2022 Aug;241:113799. doi: 10.1016/j.ecoenv.2022.113799. Epub 2022 Jun 27.
PMID: 35772359
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The exposure levels and health risk assessment of antibiotics in urine and its association with platelet mitochondrial DNA methylation in adults from Tianjin, China: A preliminary study.
Zhang J, Liu Z, Song S, Fang J, Wang L, Zhao L, Li C, Li W, Byun HM, Guo L, Li P.
Ecotoxicol Environ Saf. 2022 Jan 19;231:113204. doi: 10.1016/j.ecoenv.2022.113204. Online ahead of print.
PMID: 35065505
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2021
Environmental Genomics and Epigenomics: Response, Development and Disease
Yanqiang Li, Hyang-Min Byun, Timothy M Barrow, Qiang Zhang
Frontiers in Genetics 2021
PMID: 34093672
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Associations of adverse pregnancy outcomes with high ambient air pollution exposure: Results from the Project ELEFANT
Chen J, Fang J, Zhang Y, Xu Z, Byun HM, Li P, Deng F, Guo X, Guo L, Wu S
Science of The Total Environment 2021
PMID: 33190892
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Elevated serum mitochondrial DNA in females and lack of altered platelet mitochondrial methylation in patients with Parkinson´s disease
Sharma A, Schaefer ST, Sae-Lee C, Byun HM, Wüllner U
Int J Neurosci. 2021 Mar 3:1-4. doi: 10.1080/00207454.2020.1738433.
PMID: 32125208
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Analysis of retrotransposon subfamily DNA methylation reveals novel early epigenetic changes in chronic lymphocytic leukaemia.
Barrow TM, Wong Doo N, Milne RL, Giles GG, Willmore E, Strathdee G, Byun HM.
Haematologica. 2021 Jan 9. pii: haematol.2019.228478. doi: 10.3324/haematol.2019.228478.
PMID: 319190931
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Mitochondrial DNA methylation in placental tissue: a proof of concept study by means of prenatal environmental stressors.
Vos S, Nawrot TS, Martens DS, Byun HM, Janssen BG.
Epigenetics. 2021 Jan-Fab. doi: 10.1080/15592294.2020.1790923.
PMID: 32657220
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2020
Prenatal PM2.5 Exposure and the Risk of Adverse Births Outcomes: Results from Project ELEFANT.
Fang J, Kang CM, Osorio-Yáñez C, Barrow TM, Zhang R, Zhang Y, Li C, Liu H, Li PH, Guo L, Byun HM.
Environ Res. 2020 Sep 19:110232. doi: 10.1016/j.envres.2020.110232. Online ahead of print.
PMID: 32961173
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Environmental Epitranscriptomics
Cayir A, Byun HM, Barrow TM.
Environmental Research, 2020 https://doi.org/10.1016/j.envres.2020.109885
PMID: 32657220
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DNA methylation patterns of LINE-1 and Alu for pre-symptomatic dementia in type 2 diabetes.
Sae-Lee C, Biasi J, Robinson N, Barrow TM, Mathers JC, Koutsidis G, Byun HM.
PLoS One. 2020 Jun 11;15(6):e0234578. doi: 10.1371/journal.pone.0234578. eCollection 2020.
PMID: 32525932
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Platelet mitochondrial DNA methylation predicts future cardiovascular outcome in adults with overweight and obesity.
Corsi S, Iodice S, Vigna L, Cayir A, Mathers JC, Bollati V, Byun HM.
Clin Epigenetics. 2020 Feb 17;12(1):29. doi: 10.1186/s13148-020-00825-5.
PMID: 32066501
2019
Cayir A, Barrow TM, Guo L, Byun HM.
Environ Res. 2019 May 14;175:228-234. doi: 10.1016/j.envres.2019.05.011.
PMID: 31146095
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Barrow TM, Peng C, Wilson A, Wang H, Liu H, Shen L, Tang NJ, Sae-Lee C, Li PH, Guo L, Byun HM.
Breast Cancer Res Treat. 2019 Jan;173(1):217-224. doi: 10.1007/s10549-018-4979-4. Epub 2018 Sep 25.
PMID: 30255453
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2018
Occupational noise exposure is associated with hypertension in China: Results from project ELEFANT.
Cayir A, Barrow TM, Wang H, Liu H, Li C, Ding N, Li Y, Kang CM, Guo L, Li PH, Byun HM.
PLoS One. 2018 Dec 31;13(12):e0209041. doi: 10.1371/journal.pone.0209041. eCollection 2018.
PMID: 30596670
Dietary Intervention Modifies DNA Methylation Age Assessed by the Epigenetic Clock.
Sae-Lee C, Corsi S, Barrow TM, Kuhnle GGC, Bollati V, Mathers JC, Byun HM.
Mol Nutr Food Res. 2018 Dec;62(23):e1800092. doi: 10.1002/mnfr.201800092. Epub 2018 Nov 2.
PMID: 30350398
Xu H, Li PH, Barrow TM, Colicino E, Li C, Song R, Liu H, Tang NJ, Liu S, Guo L, Byun HM.
PLoS One. 2018 Nov 28;13(11):e0207929. doi: 10.1371/journal.pone.0207929. eCollection 2018.
PMID: 30485368
Guo L, Peng C, Xu H, Wilson A, Li PH, Wang H, Liu H, Shen L, Chen X, Qi X, Tang NJ, Barrow TM, Byun HM.
BMC Womens Health. 2018 Nov 9;18(1):182. doi: 10.1186/s12905-018-0677-y.
PMID: 30413197
Jiménez-Garza O, Guo L, Byun HM, Carrieri M, Bartolucci GB, Barrón-Vivanco BS, Baccarelli AA.
Toxicol Appl Pharmacol. 2018 Jan 15;339:65-72. doi: 10.1016/j.taap.2017.12.002. Epub 2017 Dec 5.
PMID: 29217486
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2017
Jiménez-Garza O, Guo L, Byun HM, Carrieri M, Bartolucci GB, Zhong J, Baccarelli AA.
Food Chem Toxicol. 2017 Nov;109(Pt 1):669-676. doi: 10.1016/j.fct.2017.08.019. Epub 2017 Aug 18.
PMID: 28823944
Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study.
Kresovich JK, Zhang Z, Fang F, Zheng Y, Sanchez-Guerra M, Joyce BT, Zhong J, Chervona Y, Wang S, Chang D, McCracken JP, Díaz A, Bonzini M, Carugno M, Koutrakis P, Kang CM, Bian S, Gao T, Byun HM, Schwartz J, Baccarelli AA, Hou L.
Biomarkers. 2017 Sep;22(6):584-593. doi: 10.1080/1354750X.2017.1347961. Epub 2017 Jul 26.
PMID: 28678539
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Janssen BG, Byun HM, Roels HA, Gyselaers W, Penders J, Baccarelli AA, Nawrot TS.
Clin Epigenetics. 2017 Jun 21;9:66. doi: 10.1186/s13148-017-0366-y. eCollection 2017.
PMID: 28649287
Impact of Chromosomal Rearrangement upon DNA Methylation Patterns in Leukemia.
Byun HM, Eshaghian S, Douer D, Trent J, Garcia-Manero G, Bhatia R, Siegmund K, Yang AS.
Open Med (Wars). 2017 May 4;12:76-85. doi: 10.1515/med-2017-0014. eCollection 2017.
PMID: 28730166
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Alexander M, Koutros S, Bonner MR, Barry KH, Alavanja MCR, Andreotti G, Byun HM, Chen L, Beane Freeman LE, Hofmann JN, Kamel F, Moore LE, Baccarelli A, Rusiecki J.
Environ Epigenet. 2017 May 3;3(2):dvx005. doi: 10.1093/eep/dvx005. eCollection 2017 May.
PMID: 29492307
Effects of environmental noise exposure on DNA methylation in the brain and metabolic health.
Guo L, Li PH, Li H, Colicino E, Colicino S, Wen Y, Zhang R, Feng X, Barrow TM, Cayir A, Baccarelli AA, Byun HM.
Environ Res. 2017 Feb;153:73-82. doi: 10.1016/j.envres.2016.11.017. Epub 2016 Nov 30.
PMID: 27914298
Tabish AM, Poels K, Byun HM, Luyts K, Baccarelli AA, Martens J, Kerkhofs S, Seys S, Hoet P, Godderis L.
PLoS One. 2017 Jan 12;12(1):e0169886. doi: 10.1371/journal.pone.0169886. eCollection 2017.
PMID: 28081255
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Janssen BG, Gyselaers W, Byun HM, Roels HA, Cuypers A, Baccarelli AA, Nawrot TS.
J Transl Med. 2017 Jan 4;15(1):5. doi: 10.1186/s12967-016-1113-4.
PMID: 28052772
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Rusiecki JA, Beane Freeman LE, Bonner MR, Alexander M, Chen L, Andreotti G, Barry KH, Moore LE, Byun HM, Kamel F, Alavanja M, Hoppin JA, Baccarelli A.
Environ Mol Mutagen. 2017 Jan;58(1):19-29. doi: 10.1002/em.22067. Epub 2016 Dec 20.
PMID: 27996157
The effect of morphine upon DNA methylation in ten regions of the rat brain.
Barrow TM, Byun HM, Li X, Smart C, Wang YX, Zhang Y, Baccarelli AA, Guo L.
Epigenetics. 2017;12(12):1038-1047. doi: 10.1080/15592294.2017.1398296. Epub 2018 Jan 22.
PMID: 29111854
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Alvarado-Cruz I, Sánchez-Guerra M, Hernández-Cadena L, De Vizcaya-Ruiz A, Mugica V, Pelallo-Martínez NA, Solís-Heredia MJ, Byun HM, Baccarelli A, Quintanilla-Vega B.
Mutat Res. 2017 Jan;813:27-36. doi: 10.1016/j.mrgentox.2016.11.007. Epub 2016 Nov 22.
PMID: 28010926
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2016
Peng C, Bind MC, Colicino E, Kloog I, Byun HM, Cantone L, Trevisi L, Zhong J, Brennan K, Dereix AE, Vokonas PS, Coull BA, Schwartz JD, Baccarelli AA.
Environ Health Perspect. 2016 Nov;124(11):1715-1721. Epub 2016 May 26.
PMID: 27219535
Shields AE, Wise LA, Ruiz-Narvaez EA, Seddighzadeh B, Byun HM, Cozier YC, Rosenberg L, Palmer JR, Baccarelli AA.
Epigenomics. 2016 Nov;8(11):1507-1517. Epub 2016 Sep 13.
PMID: 27620456
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Mitochondrial Epigenetics and Environmental Exposure.
Lambertini L, Byun HM.
Curr Environ Health Rep. 2016 Sep;3(3):214-24. doi: 10.1007/s40572-016-0103-2. Review.
PMID: 27344144
Byun HM, Colicino E, Trevisi L, Fan T, Christiani DC, Baccarelli AA.
J Am Heart Assoc. 2016 Apr 22;5(4). pii: e003218. doi: 10.1161/JAHA.116.003218.
PMID: 27107129
Cahill KN, Raby BA, Zhou X, Guo F, Thibault D, Baccarelli A, Byun HM, Bhattacharyya N, Steinke JW, Boyce JA, Laidlaw TM.
Am J Respir Cell Mol Biol. 2016 Jan;54(1):34-40. doi: 10.1165/rcmb.2014-0486OC.
PMID: 26051534
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2015
Jiménez-Garza O, Baccarelli AA, Byun HM, Márquez-Gamiño S, Barrón-Vivanco BS, Albores A.
Toxicol Appl Pharmacol. 2015 Aug 1;286(3):207-15. doi: 10.1016/j.taap.2015.04.016. Epub 2015 May 9.
PMID: 25963742
Platelet mitochondrial DNA methylation: a potential new marker of cardiovascular disease.
Baccarelli AA, Byun HM.
Clin Epigenetics. 2015 Apr 16;7:44. doi: 10.1186/s13148-015-0078-0. eCollection 2015.
PMID: 25901189
Byun HM, Benachour N, Zalko D, Frisardi MC, Colicino E, Takser L, Baccarelli AA.
Toxicology. 2015 Feb 3;328:152-9. doi: 10.1016/j.tox.2014.12.019. Epub 2014 Dec 19.
PMID: 25533936
Zhong J, Colicino E, Lin X, Mehta A, Kloog I, Zanobetti A, Byun HM, Bind MA, Cantone L, Prada D, Tarantini L, Trevisi L, Sparrow D, Vokonas P, Schwartz J, Baccarelli AA.
J Am Heart Assoc. 2015 Jan 27;4(1):e001423. doi: 10.1161/JAHA.114.001423. Erratum in: J Am Heart Assoc. 2016;5(1). pii: e002008. doi: 10.1161/JAHA.115.002008.
PMID: 25628407
Burris HH, Baccarelli AA, Byun HM, Cantoral A, Just AC, Pantic I, Solano-Gonzalez M, Svensson K, Tamayo y Ortiz M, Zhao Y, Wright RO, Téllez-Rojo MM.
Epigenetics. 2015;10(10):913-21. doi: 10.1080/15592294.2015.1078963. Epub 2015 Aug 7.
PMID: 26252179
Janssen BG, Byun HM, Gyselaers W, Lefebvre W, Baccarelli AA, Nawrot TS.
Epigenetics. 2015;10(6):536-44. doi: 10.1080/15592294.2015.1048412.
PMID: 25996590
Sanchez-Guerra M, Zheng Y, Osorio-Yanez C, Zhong J, Chervona Y, Wang S, Chang D, McCracken JP, Díaz A, Bertazzi PA, Koutrakis P, Kang CM, Zhang X, Zhang W, Byun HM, Schwartz J, Hou L, Baccarelli AA.
Epigenetics. 2015;10(7):633-42. doi: 10.1080/15592294.2015.1050174.
PMID: 25970091
Assessment of Changes in Global DNA Methylation Levels by Pyrosequencing® of Repetitive Elements.
Tabish AM, Baccarelli AA, Godderis L, Barrow TM, Hoet P, Byun HM.
Methods Mol Biol. 2015;1315:201-7. doi: 10.1007/978-1-4939-2715-9_15.
PMID: 26103901
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Analysis of pollutant-induced changes in mitochondrial DNA methylation.
Byun HM, Barrow TM.
Methods Mol Biol. 2015;1265:271-83. doi: 10.1007/978-1-4939-2288-8_19.
PMID: 25634281
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2014
Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders: a repeated-measures panel study.
Fan T, Fang SC, Cavallari JM, Barnett IJ, Wang Z, Su L, Byun HM, Lin X, Baccarelli AA, Christiani DC.
BMC Public Health. 2014 Dec 16;14:1279. doi: 10.1186/1471-2458-14-1279.
PMID: 25512264
Nutrients intake is associated with DNA methylation of candidate inflammatory genes in a population of obese subjects.
Bollati V, Favero C, Albetti B, Tarantini L, Moroni A, Byun HM, Motta V, Conti DM, Tirelli AS, Vigna L, Bertazzi PA, Pesatori AC.
Nutrients. 2014 Oct 22;6(10):4625-39. doi: 10.3390/nu6104625.
PMID: 25340371
Prenatal exposure to mixtures of xenoestrogens and repetitive element DNA methylation changes in human placenta.
Vilahur N, Bustamante M, Byun HM, Fernandez MF, Santa Marina L, Basterrechea M, Ballester F, Murcia M, Tardón A, Fernández-Somoano A, Estivill X, Olea N, Sunyer J, Baccarelli AA.
Environ Int. 2014 Oct;71:81-7. doi: 10.1016/j.envint.2014.06.006. Epub 2014 Jun 28.
PMID: 24980756
Variation of DNA methylation in candidate age-related targets on the mitochondrial-telomere axis in cord blood and placenta.
Janssen BG, Byun HM, Cox B, Gyselaers W, Izzi B, Baccarelli AA, Nawrot TS.
Placenta. 2014 Sep;35(9):665-72. doi: 10.1016/j.placenta.2014.06.371. Epub 2014 Jul 10.
PMID: 25047690
Association between length of gestation and cervical DNA methylation of PTGER2 and LINE 1-HS.
Burris HH, Baccarelli AA, Motta V, Byun HM, Just AC, Mercado-Garcia A, Schwartz J, Svensson K, Téllez-Rojo MM, Wright RO.
Epigenetics. 2014 Aug;9(8):1083-91. doi: 10.4161/epi.29170. Epub 2014 May 14.
PMID: 24827772
Epigenome-wide DNA methylation changes with development of arsenic-induced skin lesions in Bangladesh: a case-control follow-up study.
Seow WJ, Kile ML, Baccarelli AA, Pan WC, Byun HM, Mostofa G, Quamruzzaman Q, Rahman M, Lin X, Christiani DC.
Environ Mol Mutagen. 2014 Jul;55(6):449-56. doi: 10.1002/em.21860. Epub 2014 Feb 23.
PMID: 24677489
Effects of short-term exposure to inhalable particulate matter on DNA methylation of tandem repeats.
Guo L, Byun HM, Zhong J, Motta V, Barupal J, Zheng Y, Dou C, Zhang F, McCracken JP, Diaz A, Marco SG, Colicino S, Schwartz J, Wang S, Hou L, Baccarelli AA.
Environ Mol Mutagen. 2014 May;55(4):322-35. doi: 10.1002/em.21838. Epub 2014 Jan 17.
PMID: 24436168
Morphine induces redox-based changes in global DNA methylation and retrotransposon transcription by inhibition of excitatory amino acid transporter type 3-mediated cysteine uptake.
Trivedi M, Shah J, Hodgson N, Byun HM, Deth R.
Mol Pharmacol. 2014 May;85(5):747-57. doi: 10.1124/mol.114.091728. Epub 2014 Feb 25.
PMID: 24569088
Altered methylation in tandem repeat element and elemental component levels in inhalable air particles.
Hou L, Zhang X, Zheng Y, Wang S, Dou C, Guo L, Byun HM, Motta V, McCracken J, Díaz A, Kang CM, Koutrakis P, Bertazzi PA, Li J, Schwartz J, Baccarelli AA.
Environ Mol Mutagen. 2014 Apr;55(3):256-65. doi: 10.1002/em.21829. Epub 2013 Nov 23.
PMID: 24273195
Predicting DNA methylation level across human tissues.
Ma B, Wilker EH, Willis-Owen SA, Byun HM, Wong KC, Motta V, Baccarelli AA, Schwartz J, Cookson WO, Khabbaz K, Mittleman MA, Moffatt MF, Liang L.
Nucleic Acids Res. 2014 Apr;42(6):3515-28. doi: 10.1093/nar/gkt1380. Epub 2014 Jan 20.
PMID: 24445802
Environmental exposure and mitochondrial epigenetics: study design and analytical challenges.
Byun HM, Baccarelli AA.
Hum Genet. 2014 Mar;133(3):247-57. doi: 10.1007/s00439-013-1417-x. Epub 2014 Jan 9. Review.
PMID: 24402053
Single nucleotide polymorphisms on DNA methylation microarrays: precautions against confounding.
Barrow TM, Byun HM.
Epigenomics. 2014;6(6):577-9. doi: 10.2217/epi.14.55. No abstract available.
PMID: 25531251
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2013
Evolutionary age of repetitive element subfamilies and sensitivity of DNA methylation to airborne pollutants.
Byun HM, Motta V, Panni T, Bertazzi PA, Apostoli P, Hou L, Baccarelli AA.
Part Fibre Toxicol. 2013 Jul 15;10:28. doi: 10.1186/1743-8977-10-28.
PMID: 23855992
Storage conditions and stability of global DNA methylation in placental tissue.
Vilahur N, Baccarelli AA, Bustamante M, Agramunt S, Byun HM, Fernandez MF, Sunyer J, Estivill X.
Epigenomics. 2013 Jun;5(3):341-8. doi: 10.2217/epi.13.29.
PMID: 23750648
Association between birth weight and DNA methylation of IGF2, glucocorticoid receptor and repetitive elements LINE-1 and Alu.
Burris HH, Braun JM, Byun HM, Tarantini L, Mercado A, Wright RJ, Schnaas L, Baccarelli AA, Wright RO, Tellez-Rojo MM.
Epigenomics. 2013 Jun;5(3):271-81. doi: 10.2217/epi.13.24.
PMID: 23750643
Effects of airborne pollutants on mitochondrial DNA methylation.
Byun HM, Panni T, Motta V, Hou L, Nordio F, Apostoli P, Bertazzi PA, Baccarelli AA.
Part Fibre Toxicol. 2013 May 8;10:18. doi: 10.1186/1743-8977-10-18.
PMID: 23656717
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2012
Particulate matter, DNA methylation in nitric oxide synthase, and childhood respiratory disease.
Breton CV, Salam MT, Wang X, Byun HM, Siegmund KD, Gilliland FD.
Environ Health Perspect. 2012 Sep;120(9):1320-6. doi: 10.1289/ehp.1104439. Epub 2012 May 16.
PMID: 22591701
Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells.
Shen Y, Takahashi M, Byun HM, Link A, Sharma N, Balaguer F, Leung HC, Boland CR, Goel A.
Cancer Biol Ther. 2012 May;13(7):542-52. doi: 10.4161/cbt.19604. Epub 2012 May 1.
PMID: 22415137
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https://www.sigmaaldrich.com/catalog/papers/22415137
Global DNA methylation and low-level exposure to benzene.
Fustinoni S, Rossella F, Polledri E, Bollati V, Campo L, Byun HM, Agnello L, Consonni D, Pesatori AC, Baccarelli A, Bertazzi PA.
Med Lav. 2012 Mar-Apr;103(2):84-95.
PMID: 22619984
Mono-allelic retrotransposon insertion addresses epigenetic transcriptional repression in human genome.
Byun HM, Heo K, Mitchell KJ, Yang AS.
J Biomed Sci. 2012 Feb 2;19:13. doi: 10.1186/1423-0127-19-13.
PMID: 22300442
Increased mitochondrial DNA copy number in occupations associated with low-dose benzene exposure.
Carugno M, Pesatori AC, Dioni L, Hoxha M, Bollati V, Albetti B, Byun HM, Bonzini M, Fustinoni S, Cocco P, Satta G, Zucca M, Merlo DF, Cipolla M, Bertazzi PA, Baccarelli A.
Environ Health Perspect. 2012 Feb;120(2):210-5. doi: 10.1289/ehp.1103979. Epub 2011 Oct 17.
PMID: 22005026
Genome-scale analysis of aberrant DNA methylation in colorectal cancer.
Hinoue T, Weisenberger DJ, Lange CP, Shen H, Byun HM, Van Den Berg D, Malik S, Pan F, Noushmehr H, van Dijk CM, Tollenaar RA, Laird PW.
Genome Res. 2012 Feb;22(2):271-82. doi: 10.1101/gr.117523.110. Epub 2011 Jun 9.
PMID: 21659424
Genetic and epigenetic variations in inducible nitric oxide synthase promoter, particulate pollution, and exhaled nitric oxide levels in children.
Salam MT, Byun HM, Lurmann F, Breton CV, Wang X, Eckel SP, Gilliland FD.
J Allergy Clin Immunol. 2012 Jan;129(1):232-9.e1-7. doi: 10.1016/j.jaci.2011.09.037. Epub 2011 Nov 4.
PMID: 22055874
Temporal stability of epigenetic markers: sequence characteristics and predictors of short-term DNA methylation variations.
Byun HM, Nordio F, Coull BA, Tarantini L, Hou L, Bonzini M, Apostoli P, Bertazzi PA, Baccarelli A.
PLoS One. 2012;7(6):e39220. doi: 10.1371/journal.pone.0039220. Epub 2012 Jun 20.
PMID: 22745719
2011
DNA methylation in the arginase-nitric oxide synthase pathway is associated with exhaled nitric oxide in children with asthma.
Breton CV, Byun HM, Wang X, Salam MT, Siegmund K, Gilliland FD.
Am J Respir Crit Care Med. 2011 Jul 15;184(2):191-7. doi: 10.1164/rccm.201012-2029OC. Epub 2011 Apr 21.
PMID: 21512169
Identification of preferential target sites for human DNA methyltransferases.
Choi SH, Heo K, Byun HM, An W, Lu W, Yang AS.
Nucleic Acids Res. 2011 Jan;39(1):104-18. doi: 10.1093/nar/gkq774. Epub 2010 Sep 13.
PMID: 20841325
Increased BCR promoter DNA methylation status strongly correlates with favorable response to imatinib in chronic myeloid leukemia patients.
Koh Y, Kim DY, Park SH, Byun HM, Kim I, Yoon SS, Kim BK, Park E, Yang AS, Park S.
Oncol Lett. 2011 Jan;2(1):181-187. Epub 2010 Nov 23.
PMID: 22870150
2010
A phase I biological study of azacitidine (Vidaza™) to determine the optimal dose to inhibit DNA methylation.
Bernstein I, Byun HM, Mohrbacher A, Douer D, Gorospe G 3rd, Hergesheimer J, Groshen S, O'Connell C, Yang AS.
Epigenetics. 2010 Nov-Dec;5(8):750-7. doi: 10.4161/epi.5.8.13105. Epub 2010 Nov 1.
PMID: 20861661
Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer.
Wolff EM, Byun HM, Han HF, Sharma S, Nichols PW, Siegmund KD, Yang AS, Jones PA, Liang G.
PLoS Genet. 2010 Apr 22;6(4):e1000917. doi: 10.1371/journal.pgen.1000917.
PMID: 20421991
https://en.wikipedia.org/wiki/Long_interspersed_nuclear_element
".....Hypomethylation of a specific L1 located in the MET onco gene is associated with bladder cancer tumorogenesis,[37]"
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[37]
Wolff EM, Byun HM, Han HF, Sharma S, Nichols PW, Siegmund KD, et al. (April 2010). "Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer". PLOS Genetics.
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2009
Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns.
Byun HM, Siegmund KD, Pan F, Weisenberger DJ, Kanel G, Laird PW, Yang AS.
Hum Mol Genet. 2009 Dec 15;18(24):4808-17. doi: 10.1093/hmg/ddp445. Epub 2009 Sep 23.
PMID: 19776032
"SNPs sometimes contained in probes can interfere with methylation level detection [21]. "
Epigenomics. 2011
Evaluation of the Infinium Methylation 450K technology.
Dedeurwaerder S1, Defrance M, Calonne E, Denis H, Sotiriou C, Fuks F.
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"....as well as probes containing single-nucleotide polymorphisms (SNPs) [27]"
PLoS One. 2011
Genome-scale screen for DNA methylation-based detection markers for ovarian cancer.
Campan M1, Moffitt M, Houshdaran S, Shen H, Widschwendter M, Daxenbichler G, Long T, Marth C, Laird-Offringa IA, Press MF, Dubeau L, Siegmund KD, Wu AH, Groshen S, Chandavarkar U, Roman LD, Berchuck A, Pearce CL, Laird PW.
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Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation.
Breton CV, Byun HM, Wenten M, Pan F, Yang A, Gilliland FD.
Am J Respir Crit Care Med. 2009 Sep 1;180(5):462-7. doi: 10.1164/rccm.200901-0135OC. Epub 2009 Jun 4.
PMID: 19498054
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Changes in DNA patterns linked to prenatal smoke exposure
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Changes in DNA methylation of tandem DNA repeats are different from interspersed repeats in cancer.
Choi SH, Worswick S, Byun HM, Shear T, Soussa JC, Wolff EM, Douer D, Garcia-Manero G, Liang G, Yang AS.
Int J Cancer. 2009 Aug 1;125(3):723-9. doi: 10.1002/ijc.24384.
PMID: 19437537
2008
Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.
Yoo CB, Chuang JC, Byun HM, Egger G, Yang AS, Dubeau L, Long T, Laird PW, Marquez VE, Jones PA.
Cancer Prev Res (Phila). 2008 Sep;1(4):233-40. doi: 10.1158/1940-6207.CAPR-07-0008. Epub 2008 Mar 19.
PMID: 19138966
https://en.wikipedia.org/wiki/Zebularine
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2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1.
Byun HM, Choi SH, Laird PW, Trinh B, Siddiqui MA, Marquez VE, Yang AS.
Cancer Lett. 2008 Aug 8;266(2):238-48. doi: 10.1016/j.canlet.2008.02.069. Epub 2008 May 21.
PMID: 18499340
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Patent
N4 modifications of pyrimidine analogs and uses thereof US 20080234223 A1, 2007
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2007
Examination of IGF2 and H19 loss of imprinting in bladder cancer.
Byun HM, Wong HL, Birnstein EA, Wolff EM, Liang G, Yang AS.
Cancer Res. 2007 Nov 15;67(22):10753-8.
PMID: 18006818
Hydroxycarbamide in combination with azacitidine or decitabine is antagonistic on DNA methylation inhibition.
Choi SH, Byun HM, Kwan JM, Issa JP, Yang AS.
Br J Haematol. 2007 Sep;138(5):616-23.
PMID: 17686055
Biodistribution and tissue expression kinetics of plasmid DNA complexed with polyethylenimines of different molecular weight and structure.
Jeong GJ, Byun HM, Kim JM, Yoon H, Choi HG, Kim WK, Kim SJ, Oh YK.
J Control Release. 2007 Mar 12;118(1):118-25. Epub 2006 Dec 15.
PMID: 17250923
Changes in DNA methylation patterns in subjects exposed to low-dose benzene.
Bollati V, Baccarelli A, Hou L, Bonzini M, Fustinoni S, Cavallo D, Byun HM, Jiang J, Marinelli B, Pesatori AC, Bertazzi PA, Yang AS.
Cancer Res. 2007 Feb 1;67(3):876-80.
PMID: 17283117
Enhanced brain targeting efficiency of intranasally administered plasmid DNA: an alternative route for brain gene therapy.
Han IK, Kim MY, Byun HM, Hwang TS, Kim JM, Hwang KW, Park TG, Jung WW, Chun T, Jeong GJ, Oh YK.
J Mol Med (Berl). 2007 Jan;85(1):75-83. Epub 2006 Nov 7.
PMID: 17089096
2006
Rapid and quantitative method of allele-specific DNA methylation analysis.
Wong HL, Byun HM, Kwan JM, Campan M, Ingles SA, Laird PW, Yang AS.
Biotechniques. 2006 Dec;41(6):734-9.
PMID: 17191619
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...thus allowing for separate analysis of maternal and paternal alleles.[8]​
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...thus allowing for separate analysis of maternal and paternal alleles.[8]
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2005
Plasmid vectors harboring cellular promoters can induce prolonged gene expression in hematopoietic and mesenchymal progenitor cells.
Byun HM, Suh D, Jeong Y, Wee HS, Kim JM, Kim WK, Ko JJ, Kim JS, Lee YB, Oh YK.
Biochem Biophys Res Commun. 2005 Jul 1;332(2):518-23.
PMID: 15893736
2004
Erythrocyte ghost-mediated gene delivery for prolonged and blood-targeted expression.
Byun HM, Suh D, Yoon H, Kim JM, Choi HG, Kim WK, Ko JJ, Oh YK.
Gene Ther. 2004 Mar;11(5):492-6.
PMID: 14973541
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Patent
‘Erythrocyte ghosts containing a desired gene for biocompatible gene systems’ Korea Patent, Registration Date; 27 December 2004
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2003
Enhanced immunogenicity of DNA fusion vaccine encoding secreted hepatitis B surface antigen and chemokine RANTES.
Kim SJ, Suh D, Park SE, Park JS, Byun HM, Lee C, Lee SY, Kim I, Oh YK.
Virology. 2003 Sep 15;314(1):84-91.
PMID: 14517062
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2002
Cloning of ribosomal protein S6 kinase cDNA and its involvement in meiotic maturation in Rana dybowskii oocytes.
Byun HM, Kang SG, Kang HM.
Mol Cells. 2002 Aug 31;14(1):16-23.
PMID: 12243347